Trolamine salicylate
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| Names | |
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| Preferred IUPAC name
2-Hydroxy-N,N-bis(2-hydroxyethyl)ethan-1-aminium 2-hydroxybenzoate | |
| Other names | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.016.847 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C13H21NO6 | |
| Molar mass | 287.312 g·mol−1 |
| Appearance | Beige crystals or lumps[1] |
| Odor | odorless |
| Melting point | 50 °C (122 °F; 323 K) [3] |
| Boiling point | Decomposes[2] |
| Soluble,[2] 11.3 mg/mL (predicted)[3] | |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
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Serious eye damage |
| GHS labelling: | |
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| Warning | |
| H302, H315, H319, H335 | |
| P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P312, P317, P319, P321, P330, P332, P337, P362+P364, P403+P233, P405, P501 | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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500 mg/kg (oral, estimated value)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Trolamine salicylate (Aspercreme, Aspergel) is an organic compound with the chemical formula [HN(CH2CH2OH)3]+C6H4(OH)(COO−). It is a salt of triethanolamine and salicylic acid, i.e. the compound consists of protonated triethanolamine and the conjugate base of salicylic acid, salicate.
It is used as an ingredient in sunscreens, analgesic creams, and cosmetics. The salicylic acid portion contributes to both the sun protection effect (by absorbing UVB radiation) and to the analgesic effect. The triethanolamine neutralizes the acidity of the salicylic acid. One benefit of this topical analgesic is that it has no odor, in contrast to other topical analgesics such as menthol.
The US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the Daily Med database that contain trolamine salicylate.[4] Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue.[5] Due to health concerns, in 2019 the FDA issued a proposed rule classifying the sunscreen use of trolamine salicylate as "not generally recognized as safe and effective."[6] One study reported that trolamine salicylate does penetrate into, and persist within, underlying muscle tissue. The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to induce muscle soreness. The experimenters observed that those using the trolamine salicylate product exercised longer before reporting the onset of soreness, reported less intense soreness, and reported that their soreness did not last as long as the people who used the placebo.[7]
All of the trolamine salicylate-containing products listed in the two cited references are 10% solutions. These products are sold under various brand names, e.g. Aspercreme, and are marketed as topical analgesics for temporary relief of arthritis, simple backache, muscle strains, and sprains.
See also
[edit]References
[edit]- ^ a b c d Safety data sheet
- ^ a b c d "Trolamine salicylate".
- ^ a b "Trolamine salicylate".
- ^ From DailyMed (a publication of the National Institutes of Health) [1],[dead link] retrieved 23 April 2011
- ^ Steven Pray, Nonprescription Product Therapeutics, 2nd ed., Lippincott Williams & Wilkins (2006), ISBN 0-7817-3498-3, ISBN 978-0-7817-3498-1
- ^ FDA News Release, (FDA advances new proposed regulation to make sure that sunscreens are safe and effective) [2], retrieved 13 December 2019
- ^ "Effect of a Topical 10% Trolamine Salicylate Cream on Delayed Onset Muscular Soreness", Medicine and Science in Sports and Exercise, vol. 20(2), Supplement, #141 (1988), online at Peak Performance website[dead link] retrieved 23 April 2011
Truly Komal Blog. (2024). Topical Analgesic Creams for Pain Relief: Effective Treatment or Just a Marketing Fad? Truly Komal. Retrieved from [1]